The 17-year-olds are being questioned over the killing of Munashe Charles Kutyauripo known as Charlie in Woodford, east London, on 9 January.
He had been at a female friend's 16th birthday party at Ashton playing fields when a confrontation took place outside the social club.
A third suspect, 16-year-old Aaron Alexander Tavares-Gaiete, is wanted by police.
Charlie who was stabbed in the chest, and died an hour later at Whipps Cross Hospital was the first teenager murdered in London this year.
Charlie who was stabbed in the chest, and died an hour later at Whipps Cross Hospital was the first teenager murdered in London this year.

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